A recent study suggests that cholesterol levels may play a role in how bladder cancer grows and spreads.
Researchers identified a protein called PIN1 that triggers the body to produce more cholesterol, which in turn appears to help tumors grow.
In experiments with mice, the team found that combining a cholesterol-lowering drug, simvastatin, with an experimental PIN1 inhibitor called sulfopin was particularly effective at slowing tumor growth.
This combination not only reduced cholesterol levels but also blocked the molecular pathway that cancer cells rely on to multiply.
While these findings are promising, more research is needed to determine if this approach will be safe and effective in humans. The study opens new avenues for treatments that target cholesterol metabolism as a way to help prevent the progression of bladder cancer.
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